Antiepileptic effects of antioxidant potent extract from Urtica dioica Linn. root on pentylenetetrazole and maximal electroshock induced seizure models
نویسندگان
چکیده
منابع مشابه
Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans?
PURPOSE Pentylenetetrazole and maximal electroshock rodent seizure models are commonly used to detect antiepileptic efficacy in drug development. The aim of this research was to evaluate the predictive capabilities of pentylenetetrazole and maximal electroshock models in estimating human exposures required for antiepileptic efficacy through a survey of current literature. METHODS A literature...
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The aim of the present study was to isolate hepatoprotective component from Urtica dioica Linn. (whole plant) against CCl4-induced hepatotoxicity in-vitro (HepG2 cells) and in-vivo (rats) model. Antioxidant activity of hydro alcoholic extract and its fractions petroleum ether fraction (PEF), ethyl acetate fraction (EAF), n-butanol fraction (NBF) and aqueous fraction (AF) were determined by DPPH...
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Introduction: Stinging nettle (Urtica dioica L.) is the most important genus in the plant family Urticaceae. Urtica Dioica root Extract (UDE) is widely used for the treatment of prostate hyperplasia. Side effects of UDE were not studied on other organs such as testes (an important organ of the male reproductive system). Furthermore, antagonist effects of UDE on testosterone were considered. The...
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Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...
متن کاملAntinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models
OBJECTIVE This study was aimed to examine the antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. MATERIALS AND METHODS Hydroalcoholic extract of the plant leaves was prepared by percolation method. Male Swiss mice (25-35 g) and male Wistar rats (180-200 g) were randomly distributed in control, standard drug, and three experimental groups (n=6 in each...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2021
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2021.e06195